Modafinil, also known as Provigil is designed to treat the symptoms of narcolepsy, shift work sleep disorder, and obstructive sleep apnea. The pharmaceutical drug helps with the sensation of sleepiness that is typically caused by these conditions and promotes wakefulness. While it may be found under multiple names, the drug comes in the shape of pills that must be taken by mouth. Modafinil has been approved by the FDA in the US in 1998 and is classified as a schedule IV-controlled substance.
The recommended dosage of Modafinil that should be taken depends greatly on the affection that you may have. Here is how the drug should be taken according to the various illnesses that it treats:
- Narcolepsy: 200mg, orally, in the morning;
- Obstructive Sleep Apnea (OSA) or Hypopnea: 200mg, orally, in the morning;
- Shift Word Sleep Disorder: 200mg, orally, one hour before starting the shift;
It is important to mention the fact that Modafinil only treats the symptoms of OSA, not the cause of the illness. Furthermore, the dosage specified above represents the usual dose for a healthy adult. Those who suffer from liver or kidney disease may require to adjust the treatment in order to avoid worsening those conditions.
Generally speaking, it is advisable to only take Modafinil after consulting a doctor, to ensure that you are healthy enough to take full doses and that you are not allergic to any of the ingredients of the drug.
What are the side effects of Modafinil?
While Modafinil itself is relatively safe to use by anyone. However, there are side effects that are potentially life-threatening, although these rarely occur and can be easily treated in a hospital. These are:
- Back pain;
- Difficulty sleeping;
In rare cases, in which an individual is allergic to one of the active ingredients, powerful skin reactions can occur. Upon suffering severe skin rashes and peeling caused by Modafinil the treatment should be immediately stopped, followed by an urgent appointment with a doctor, or a trip to the hospital for further investigations.
The allergic reactions are extremely rare and only tend to become life-threatening if an individual does not stop taking the drug after experiencing the symptoms. These also present with swelling in the legs, mouth sores, dark urine, difficulty breathing and swallowing, and yellowing of the skin and eyes.
What are the withdrawal symptoms of Modafinil?
Modafinil is designed to be taken regularly in order to maximize its effects on the body, however, this does also mean that individuals who take it for too long and then stop may go through withdrawal symptoms. The withdrawal symptoms of the drug are rarely linked to psychological addiction, where a person feels the urge to take more. In most cases, they are the result of the fact that the body becomes accustomed to having the drug in its system.
Withdrawal symptoms include:
Please keep in mind that withdrawal does not present itself every time an individual takes Modafinil for a longer period of time. They are much more likely to appear in the case of those who take it for more than a couple of months, and their strength depends on the doses and the frequency with which they were taken.
The withdrawal symptoms of Modafinil can be avoided, in a large part, by taking increasingly smaller doses before finally stopping using the drug completely. This will ease the body off, lowering the strength of the side effects to a manageable level.
Working time of Modafinil
Once taken, the Modafinil pill’s effects will be felt in 30 to 60 minutes. Once it enters the bloodstream, the drug has a half-life of approximately 12 hours, however, in some cases, its effects can last for up to 15 hours. This depends on the amount of exercise that an individual gets, as well as his or her weight.
There are also certain genetic predispositions and kidney and liver illnesses that can prolong the effects to a greater extent.
Can Modafinil be taken with alcohol?
Mixing Modafinil with alcohol is not advised as it can lead to a large number of complications such as the decreased effectiveness of the drug and blackouts.
Where to buy Modafinil online?
Modafinil is a prescription pharmaceutical drug and its commercialization is strictly regulated by the government. As a result, the safest place to purchase it is from a physical pharmacy. However, there are multiple online drug stores that can sell Modafinil, provided that you provide them with proof of the prescription.
There are also numerous online pharmacies that claim to sell the drug. These are not regulated by the government and should not be trusted. Purchasing prescription medicine from these websites is not only illegal but also extremely dangerous as there is no way of actually knowing what you are being sold.
Most illegal online pharmacies replace the prescription drugs with placebos, or with other substances that mimic their effects, to an extent.
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Websites such as Drugs.com and webmd.com rate Modafinil with 7.8/10 respectively 4.3/5 stars, on average. Individuals who have taken the drug are largely pleased with the strength of its effects both when taking it, as well as over the course of several months. Those who take Modafinil mention the fact that the side effects are rarely felt and the withdrawal symptoms after prolonged use are easily managed.
There are also statements on webmd.com that come from people who have been taken Modafinil for over 10 years without experiencing any side effects.
Overall, the drug has been in use for several years and has been tried and tested multiple times. It is currently considered to be one of the most efficient pharmaceutical drugs that can be used in order to treat the symptoms of narcolepsy, shift work sleep disorder, and obstructive sleep apnea.
Modafinil Medical Research
There have been over 24 research studies, over the years, meant to further verify the efficiency of Modafinil, as well as to determine how safe it is when used for extended periods of time. The more recent ones, such as published in 2015 in the European Neuropsychopharmacology journal, a peer-reviewed publication, have taken other possibilities into consideration.
The study shows that, while the drug is known to be extremely effective when used by individuals who have a condition such as shift work sleep disorder and narcolepsy, however, it may also function as a cognitive enhancer for healthy people. As a result, the study has triggered several new research projects that hope to uncover how Modafinil can be used by healthy people, on a regular basis, in order to enhance their ability to work and process information.
Another study, the “Mechanisms of modafinil: A review of current research”, published in 2007 shows that the drug can truly stimulate the brain and even improve its function, by increasing the power of the alpha waves and decreasing that of the theta ones. These changes are consistent with the observed effects of Modafinil on the brain.
Overall, most medical studies related to how Modafinil affects the brain proves the fact that the drug is not only extremely effective at promoting wakefulness but also safe to use for extended periods of time. This includes studies done when designing the drug, as well as more recent ones that are now also exploring its effects on healthy individuals or the condition of their brains after 15+ years of treatment.
Furthermore, it is important to mention that the tools used in these studies have been electronic, such as computer imaging, and surgical, enabling specialists to analyze all the effects of Modafinil.